Postdoc in Synaptic Transmission of Animal Disease Models at Department of Neuroscience at University of Copenhagen, Denmark.

We are looking for a highly motivated and dynamic researcher with interest in synaptic transmission for a 3-year position to start at December 1st 2019 or after agreement.

The position is part of the project “Neurodevelopmental disorders and the synapse” funded by the Lundbeckfonden call “What Causes Brain Disease?”. The projectinvolves novel human and animal models for neurodevelopmental disorders caused by mutation of the synaptic release machinery, as well as systematic comparison to human patient and EEG data. We hypothesize that an imbalance in the ratio between excitatory and inhibitory neurotransmission leads to hyperexcitability and Intellectual Disability.

Our research groups (Sørensen and Perrier groups) are highly interdisciplinary and international. Sørensen’s work is focused on understanding the molecular mechanism of synaptic transmission and neurotransmitter release. Information on the Sørensen group can be found on https://in.ku.dk/research/jakob-balslev-soerensen/. The Perrier group has a strong interest in the endogenous properties of neurons and in mechanisms behind epilepsy. Information on the Perrier group can be found on https://in.ku.dk/research/jean-francois-perrier/.

We offer creative and stimulating working conditions in Copenhagen with modern laboratories in the new architectural pearl of the North, the ‘Mærsk Tower’, https://maersktower.ku.dk/.

The specific aim of the current position is to investigate synaptic transmission within identified micronetworks in the brain, whose dysfunction might underlie cortical hyperexcitability and intellectual disability. You will perform double patch- clamp recordings in the hippocampus and neocortex of novel mouse disease models. Using a combination of electrophysiology and optics (optogenetics) you will characterize feedforward and feedback inhibition circuits.

To view the detailed requirements and apply for the position, please visit this link:https://jobportal.ku.dk/videnskabelige-stillinger/?show=150164.