Basic Kinetic Modeling in PET and MR Imaging
09:00 24th February 2020 to 16:00 28th February 2020
Rigshospitalet, the Rockefeller Building, Juliane Maries Vej 28 Get directions

DEADLINE 3. February 2020

ECTS -credits: 3.6 points


Aspects covered: basic mathematics, introduction to SPECT, PET, and MRI, steady state,indicator diffusion, Fick's principle, clearance, extraction, mean transit time, convolution and impulse response, residue detection, Kety-Schmidt method, receptor kinetics and
quantification, models of glucose consumption (Sokoloff), water exchange and perfusion measurement, practical exercises on simulated and real datasets. The participants are encouraged to present and discuss their own projects.

Learning objectives

  1. Explain tracer kinetic principles in physiology, nuclear medicine and magnetic resonance
    imaging (MRI).
  2. Define Fick’s principle, compartments and rate constants
  3. Theorize on impulse response function, exponential functions and convolution
  4. Reflect on own project from a tracer kinetic perspective
  5. Use software for tracer kinetic modeling approaches
  6. Evaluate and select among kinetic models used for performing kinetic analysis of
    dynamic datasets


Gitte Moos Knudsen, professor, DMSc, Neurobiology Research Unit, Rigshospitalet
Henrik B.W. Larsson, professor, DMSc, Functional and diag. MR Unit, Rigshospitalet-Glostrup
Adam Espe Hansen, MD, PhD, Dept. Clinical Physiology, Rigshospitalet
Karen Kettless, MRI Applications Specialist, Siemens Healthineers
Adriaan Lammertsma, Professor, VU University Medical Center, Amsterdam, The Netherlands
Ian Law, MD, DMSc, Dept. Clinical Physiology, Rigshospitalet
Lisbeth Marner, PhD, MD, Dept. Clinical Physiology, Rigshospitalet
Esben Thade Pedersen, MR Dept, Hvidovre Hospital
Martin Schain, MSc, PhD, Neurobiology Research Unit, Rigshospitalet
Claus Svarer, PhD, Neurobiology Research Unit, Rigshospitalet


PhD students in medicine, biophysics, physics, chemistry, and biology. Graduates with interest in this field.




Interactive teaching with examples and PC exercises.




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